Reruns of the original The Mickey Mouse Club began airing on The Disney Channel with the channel's 1983 launch. While the show was popular with younger audiences, the Disney Channel executives felt it had become dated over the years, particularly as it was aired in black-and-white. Their answer was to create a brand-new version of the club, one aimed toward contemporary audiences. Notably, the all-new "club-members" would wear Mouseketeer varsity jackets without the iconic Mickey Mouse ears. This show was called The All-New Mickey Mouse Club (also known as "MMC" to fans).
This version of the series is notable for featuring a number of cast members who went on to achieve global success in music and acting, including Canadian actor Ryan Gosling, Britney Spears, Christina Aguilera, future NSYNC band members Justin Timberlake and JC Chasez, Keri Russell, Deedee Magno, future En Vogue member Rhona Bennett, Nikki DeLoach, and Chase Hampton. Nick Carter was selected to join the program at the age of 12, however, he decided to join the developing boy band, Backstreet Boys.
Throughout the run, Fred Newman was the main adult co-host from the beginning of the series until season 6. In the first season, Newman was joined by other co-host Mowava Pryor. She was then replaced by Terri Eoff from the fourth season until the sixth season. By the show's final season, two original members Chase Hampton and Tiffini Hale became the co-hosts.
This was the first version of the club to have any studio audience, though a fairly small group.
Former Mouseketeer Don Grady guest-starred in the show's first-season finale. Grady, along with fellow Mouseketeers Annette Funicello, Bobby Burgess, Tommy Cole, Sharon Baird, and Sherry Alberoni were reunited on the 100th episode, during the show's third season. Funicello later appeared on the show again, in an interview with the Mouseketeer Lindsey Alley.